{"id":138370,"date":"2024-12-18T10:32:30","date_gmt":"2024-12-18T03:32:30","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=138370"},"modified":"2024-12-18T10:32:30","modified_gmt":"2024-12-18T03:32:30","slug":"9-of-the-most-genetically-isolated-human-populations-in-the-world","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=138370","title":{"rendered":"9 of the most &#8216;genetically isolated&#8217; human populations in the world"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div itemprop=\"articleBody\" id=\"article-body\">\n<p>Over the past 50,000 years, humans have populated nearly every corner of the globe \u2014 and due to geographic barriers, some of these populations then remained isolated for thousands or even tens of thousands of years.<\/p>\n<p>Other populations have become cloistered thanks to insular cultural or religious practices. As a result, the genetic diversity of our species has declined over the past 50 millennia.<\/p>\n<aside class=\"hawk-nest\" data-block-type=\"embed\" data-render-type=\"fte\" data-skip=\"dealsy\" data-widget-type=\"seasonal\"\/>\n<p>Genetic diversity in a given population can be reduced in what is known as a &#8220;founder event&#8221; \u2014 when a small group of people splits off from a larger population, which leads to a smaller gene pool in the isolated group. In a study of 460 populations around the world, roughly half showed evidence of a recent founder event, <a data-analytics-id=\"inline-link\" href=\"https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1010243\" target=\"_blank\" data-url=\"https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1010243\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>researchers concluded in 2022<\/u><\/a>.<\/p>\n<p>Here&#8217;s a look at some of the most genetically isolated groups of modern humans \u2014 and how these <a data-analytics-id=\"inline-link\" href=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/gb-2008-9-8-109\" target=\"_blank\" data-url=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/gb-2008-9-8-109\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>isolated populations are helping researchers<\/u><\/a> better understand humans&#8217; unique abilities and diseases that affect some groups more than others.<\/p>\n<h2 id=\"1-anabaptists-amish-mennonites-and-hutterites-3\">1. Anabaptists \u2014 Amish, Mennonites and Hutterites<\/h2>\n<figure class=\"van-image-figure inline-layout\" data-bordeaux-image-check=\"\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\" style=\"max-width:6010px;\">\n<p class=\"vanilla-image-block\" style=\"padding-top:56.26%;\"><picture><source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-320-80.jpg.webp 320w, https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-1200-80.jpg.webp 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\"\/><img decoding=\"async\" alt=\"Seven Amish people ride in a horse-drawn buggy on a road in a lush green landscape\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-320-80.jpg 320w, https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-480-80.jpg 480w, https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-650-80.jpg 650w, https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-970-80.jpg 970w, https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-1024-80.jpg 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3-1200-80.jpg 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\" loading=\"lazy\" src=\"https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3.jpg\" data-pin-media=\"https:\/\/cdn.mos.cms.futurecdn.net\/xweGdnpyBoSXrbx6G3FwC3.jpg\"\/><\/picture><\/p>\n<\/div>\n<\/div><figcaption itemprop=\"caption description\" class=\" inline-layout\"><span class=\"credit\" itemprop=\"copyrightHolder\">(Image credit: Cavan Images\u00a0\/ Alamy\u00a0Stock Photo)<\/span><\/figcaption><\/figure>\n<p>These Christian groups originated in the 16th century, and many moved to America in the 17th century, settling in rural areas such as southeastern Pennsylvania. All of these populations have had significant founder effects and genetic bottlenecks over the past few centuries, and in 2011, a database was created to keep track of genetic disorders <a data-analytics-id=\"inline-link\" href=\"https:\/\/doi.org\/10.1093\/pch\/16.3.e23\" target=\"_blank\" data-url=\"https:\/\/doi.org\/10.1093\/pch\/16.3.e23\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>common to the Anabaptists<\/u><\/a>.<\/p>\n<p>For example, <a data-analytics-id=\"inline-link\" href=\"https:\/\/medlineplus.gov\/genetics\/condition\/maple-syrup-urine-disease\/#frequency\" target=\"_blank\" data-url=\"https:\/\/medlineplus.gov\/genetics\/condition\/maple-syrup-urine-disease\/#frequency\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>maple syrup urine disease<\/u><\/a>, an inherited condition that involves problems processing the amino acids that make up proteins, is rare in the general population but affects <a data-analytics-id=\"inline-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/ajmg.c.20003\" target=\"_blank\" data-url=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/ajmg.c.20003\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>1 in 380 Old Order Mennonites<\/u><\/a>. And the modern Hutterites descend from just 67 people, which has resulted in a higher than average rate of <a data-analytics-id=\"inline-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1684350\/\" target=\"_blank\" data-url=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1684350\/\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>cystic fibrosis<\/u><\/a> within the population.<\/p>\n<h2 id=\"2-parsis-3\">2. Parsis<\/h2>\n<figure class=\"van-image-figure inline-layout\" data-bordeaux-image-check=\"\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\" style=\"max-width:5366px;\">\n<p class=\"vanilla-image-block\" style=\"padding-top:56.24%;\"><picture><source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-320-80.jpg.webp 320w, https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-1200-80.jpg.webp 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\"\/><img decoding=\"async\" alt=\"Four women sit by the sea and pray\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-320-80.jpg 320w, https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-480-80.jpg 480w, https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-650-80.jpg 650w, https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-970-80.jpg 970w, https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-1024-80.jpg 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn-1200-80.jpg 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\" loading=\"lazy\" src=\"https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn.jpg\" data-pin-media=\"https:\/\/cdn.mos.cms.futurecdn.net\/wKsKEx7ceKTvLfACfHrFAn.jpg\"\/><\/picture><\/p>\n<\/div>\n<\/div><figcaption itemprop=\"caption description\" class=\" inline-layout\"><span class=\"caption-text\">Four Parsi women sit by the sea to pray <\/span><span class=\"credit\" itemprop=\"copyrightHolder\">(Image credit: Dinodia Photos\u00a0\/ Alamy\u00a0Stock Photo)<\/span><\/figcaption><\/figure>\n<p>The Parsis are a community of Zoroastrians who migrated to India from Persia in the seventh century. Traditional Parsis disapprove of marriage outside of their religion, which may have led to <a data-analytics-id=\"inline-link\" href=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/s13059-017-1244-9\" target=\"_blank\" data-url=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/s13059-017-1244-9\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>the group&#8217;s isolation<\/u><\/a>.<\/p>\n<p>Geneticists are particularly interested in the longevity of the Parsis, who have gene variants correlated with living well into their 90s, despite the higher-than-average rate of breast cancer in women. A 2021 study published in <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2214540021000335\" target=\"_blank\" data-url=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2214540021000335\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>Meta Gene<\/u><\/a> concluded that the Parsi practice of endogamy \u2014 marrying within their group \u2014 was likely the reason for these particular traits.<\/p>\n<h2 id=\"3-sherpa-3\">3. Sherpa <\/h2>\n<figure class=\"van-image-figure inline-layout\" data-bordeaux-image-check=\"\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\" style=\"max-width:5611px;\">\n<p class=\"vanilla-image-block\" style=\"padding-top:56.25%;\"><picture><source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-320-80.jpg.webp 320w, https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-1200-80.jpg.webp 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\"\/><img decoding=\"async\" alt=\"A group of Sherpa walk up a mountain in the Everest region\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-320-80.jpg 320w, https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-480-80.jpg 480w, https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-650-80.jpg 650w, https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-970-80.jpg 970w, https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-1024-80.jpg 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP-1200-80.jpg 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\" loading=\"lazy\" src=\"https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP.jpg\" data-pin-media=\"https:\/\/cdn.mos.cms.futurecdn.net\/BcMLH9F5xzdTR2RrjPvCKP.jpg\"\/><\/picture><\/p>\n<\/div>\n<\/div><figcaption itemprop=\"caption description\" class=\" inline-layout\"><span class=\"caption-text\">A group of Sherpa walk up a mountain in the Everest region of Nepal <\/span><span class=\"credit\" itemprop=\"copyrightHolder\">(Image credit: Neil White\u00a0\/ Alamy\u00a0Stock Photo)<\/span><\/figcaption><\/figure>\n<p>The Sherpa in the mountains of Nepal have remained genetically isolated for centuries, likely in part because of the forbidding landscape they inhabit. The group moved from Tibet between 400 and 600 years ago and are best known as <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.livescience.com\/45041-mt-everest-why-do-people-keep-climbing-it.html\" data-before-rewrite-localise=\"https:\/\/www.livescience.com\/45041-mt-everest-why-do-people-keep-climbing-it.html\"><u>highly skilled Mt. Everest guides<\/u><\/a>. Although the Sherpa have plenty of neighbors, a 2017 study in the journal <a data-analytics-id=\"inline-link\" href=\"https:\/\/doi.org\/10.1186\/s12864-016-3469-5\" target=\"_blank\" data-url=\"https:\/\/doi.org\/10.1186\/s12864-016-3469-5\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>BMC Genomics<\/u><\/a> showed that their genome has little evidence of gene flow from nearby Nepali groups.<\/p>\n<p>Geneticists are particularly interested in the Sherpa&#8217;s ability to thrive at high altitudes, which a 2014 study in the journal <a data-analytics-id=\"inline-link\" href=\"https:\/\/go.redirectingat.com\/?id=92X1590019&amp;xcust=livescience_us_1171221781922541958&amp;xs=1&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fncomms4281&amp;sref=https%3A%2F%2Fwww.livescience.com%2Fhealth%2F9-of-the-most-genetically-isolated-human-populations-in-the-world\" target=\"_blank\" data-url=\"https:\/\/www.nature.com\/articles\/ncomms4281\" referrerpolicy=\"no-referrer-when-downgrade\" rel=\"sponsored noopener\" data-hl-processed=\"skimlinks\" data-placeholder-url=\"https:\/\/go.redirectingat.com\/?id=92X1590019&amp;xcust=hawk-custom-tracking&amp;xs=1&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fncomms4281&amp;sref=https%3A%2F%2Fwww.livescience.com%2Fhealth%2F9-of-the-most-genetically-isolated-human-populations-in-the-world\" data-google-interstitial=\"false\" data-merchant-name=\"SkimLinks - nature.com\" data-merchant-id=\"undefined\" data-merchant-url=\"undefined\" data-merchant-network=\"undefined\"><u>Nature Communications<\/u><\/a> found to be linked to the groups&#8217; unique genetics that likely evolved within the last three millennia.<\/p>\n<h2 id=\"4-papua-new-guineans-3\">4. Papua New Guineans<\/h2>\n<figure class=\"van-image-figure inline-layout\" data-bordeaux-image-check=\"\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\" style=\"max-width:1920px;\">\n<p class=\"vanilla-image-block\" style=\"padding-top:56.25%;\"><picture><source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-320-80.jpg.webp 320w, https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-1200-80.jpg.webp 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\"\/><img decoding=\"async\" alt=\"Nine members of a family are pictured sitting on a wooden platform with clothes hanging on a washing line above. Their smiling faces can be seen looking at the camera. Woodland can be seen in the background of the image on the right-hand side. The group appear to be sat in front of a building.\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-320-80.jpg 320w, https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-480-80.jpg 480w, https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-650-80.jpg 650w, https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-970-80.jpg 970w, https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-1024-80.jpg 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR-1200-80.jpg 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\" loading=\"lazy\" src=\"https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR.jpg\" data-pin-media=\"https:\/\/cdn.mos.cms.futurecdn.net\/dfxFgUujvfMHMgsnABrCgR.jpg\"\/><\/picture><\/p>\n<\/div>\n<\/div><figcaption itemprop=\"caption description\" class=\" inline-layout\"><span class=\"caption-text\">A family of Papua New Guineans sitting in front of a building <\/span><span class=\"credit\" itemprop=\"copyrightHolder\">(Image credit: Shutterstock)<\/span><\/figcaption><\/figure>\n<p>When modern humans arrived in New Guinea roughly 50,000 years ago, they met and mixed with the <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.livescience.com\/denisovans-extinct-human-relative\" data-before-rewrite-localise=\"https:\/\/www.livescience.com\/denisovans-extinct-human-relative\"><u>Denisovans<\/u><\/a>, a now-extinct group of human ancestors who originated in Asia. But after that initial meet-up, Papua New Guineans became <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.livescience.com\/health\/genetics\/papua-new-guineans-genetically-isolated-for-50000-years-carry-denisovan-genes-that-help-their-immune-system-study-suggests\" data-before-rewrite-localise=\"https:\/\/www.livescience.com\/health\/genetics\/papua-new-guineans-genetically-isolated-for-50000-years-carry-denisovan-genes-that-help-their-immune-system-study-suggests\"><u>genetically isolated<\/u><\/a> for tens of millennia \u2014 even within the country itself.<\/p>\n<p>A 2017 study published in the journal <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aan3842\" target=\"_blank\" data-url=\"https:\/\/www.science.org\/doi\/10.1126\/science.aan3842\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>Science<\/u><\/a> showed a sharp divide between the gene variants of people living in the highlands versus the lowlands. And a genome study published in the journal <a data-analytics-id=\"inline-link\" href=\"https:\/\/go.redirectingat.com\/?id=92X1590019&amp;xcust=livescience_us_5992595708945117733&amp;xs=1&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41467-024-47735-1&amp;sref=https%3A%2F%2Fwww.livescience.com%2Fhealth%2F9-of-the-most-genetically-isolated-human-populations-in-the-world\" target=\"_blank\" data-url=\"https:\/\/www.nature.com\/articles\/s41467-024-47735-1\" referrerpolicy=\"no-referrer-when-downgrade\" rel=\"sponsored noopener\" data-hl-processed=\"skimlinks\" data-placeholder-url=\"https:\/\/go.redirectingat.com\/?id=92X1590019&amp;xcust=hawk-custom-tracking&amp;xs=1&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41467-024-47735-1&amp;sref=https%3A%2F%2Fwww.livescience.com%2Fhealth%2F9-of-the-most-genetically-isolated-human-populations-in-the-world\" data-google-interstitial=\"false\" data-merchant-name=\"SkimLinks - nature.com\" data-merchant-id=\"undefined\" data-merchant-url=\"undefined\" data-merchant-network=\"undefined\"><u>Nature Communications<\/u><\/a> in 2024 showed that Papua New Guineans inherited unique gene variants from the Denisovans that may help people in the lowlands fight off infections and the people in the highlands live at high altitudes.<\/p>\n<p><strong>Related: <\/strong><a data-analytics-id=\"inline-link\" href=\"https:\/\/www.livescience.com\/health\/genetics\/gene-mutation-helps-andean-highlanders-thrive-at-altitude-and-living-fossil-fish-live-deep-underwater\" data-before-rewrite-localise=\"https:\/\/www.livescience.com\/health\/genetics\/gene-mutation-helps-andean-highlanders-thrive-at-altitude-and-living-fossil-fish-live-deep-underwater\"><u><strong>Gene mutation helps Andean highlanders thrive at altitude, and &#8216;living fossil&#8217; fish live deep underwater<\/strong><\/u><\/a><\/p>\n<h2 id=\"5-nunavik-inuit-3\">5. Nunavik Inuit<\/h2>\n<figure class=\"van-image-figure inline-layout\" data-bordeaux-image-check=\"\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\" style=\"max-width:5153px;\">\n<p class=\"vanilla-image-block\" style=\"padding-top:56.24%;\"><picture><source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-320-80.jpg.webp 320w, https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-1200-80.jpg.webp 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\"\/><img decoding=\"async\" alt=\"Two Inuit people wearing black coats work above their heads on their igloo\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-320-80.jpg 320w, https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-480-80.jpg 480w, https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-650-80.jpg 650w, https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-970-80.jpg 970w, https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-1024-80.jpg 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG-1200-80.jpg 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\" loading=\"lazy\" src=\"https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG.jpg\" data-pin-media=\"https:\/\/cdn.mos.cms.futurecdn.net\/ZFFqGR8n2urHG2wzGSqrwG.jpg\"\/><\/picture><\/p>\n<\/div>\n<\/div><figcaption itemprop=\"caption description\" class=\" inline-layout\"><span class=\"caption-text\">Two Nunavik Inuit work on building their igloo <\/span><span class=\"credit\" itemprop=\"copyrightHolder\">(Image credit: Friedrich Stark\u00a0\/ Alamy\u00a0Stock Photo)<\/span><\/figcaption><\/figure>\n<p>The North American Arctic was the last region of the world to be settled by humans, beginning roughly <a data-analytics-id=\"inline-link\" href=\"https:\/\/go.redirectingat.com\/?id=92X1590019&amp;xcust=livescience_us_8584445749050471359&amp;xs=1&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41586-019-1251-y&amp;sref=https%3A%2F%2Fwww.livescience.com%2Fhealth%2F9-of-the-most-genetically-isolated-human-populations-in-the-world\" target=\"_blank\" data-url=\"https:\/\/www.nature.com\/articles\/s41586-019-1251-y\" referrerpolicy=\"no-referrer-when-downgrade\" rel=\"sponsored noopener\" data-hl-processed=\"skimlinks\" data-placeholder-url=\"https:\/\/go.redirectingat.com\/?id=92X1590019&amp;xcust=hawk-custom-tracking&amp;xs=1&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41586-019-1251-y&amp;sref=https%3A%2F%2Fwww.livescience.com%2Fhealth%2F9-of-the-most-genetically-isolated-human-populations-in-the-world\" data-google-interstitial=\"false\" data-merchant-name=\"SkimLinks - nature.com\" data-merchant-id=\"undefined\" data-merchant-url=\"undefined\" data-merchant-network=\"undefined\"><u>6,000 years ago<\/u><\/a>. Inuit people arrived in <a data-analytics-id=\"inline-link\" href=\"https:\/\/indigenouspeoplesatlasofcanada.ca\/article\/nunavik\/\" target=\"_blank\" data-url=\"https:\/\/indigenouspeoplesatlasofcanada.ca\/article\/nunavik\/\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>Nunavik<\/u><\/a>, the northernmost part of the Canadian province of Quebec, about <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.avataq.qc.ca\/en\/Nunavimmiuts\/The-land\/The-Region-of-Nunavik\" target=\"_blank\" data-url=\"https:\/\/www.avataq.qc.ca\/en\/Nunavimmiuts\/The-land\/The-Region-of-Nunavik\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>seven or eight centuries<\/u><\/a> ago. A <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.1810388116\" target=\"_blank\" data-url=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.1810388116\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>2019 study of 170 genomes of Nunavik Inuit people<\/u><\/a> found that the Nunavik Inuit had little admixture with outside groups, leading to some unique gene variants.<\/p>\n<p>In particular, their genomes seemed to reflect an increased ability to metabolize fat and protein, important for surviving a bitterly cold climate with few plant-sources of food. But the researchers also discovered the Nunavik Inuit had a much higher-than-normal genetic risk for brain aneurysms resulting from founder effect.<\/p>\n<h2 id=\"6-antioquenos-3\">6. Antioque\u00f1os<\/h2>\n<figure class=\"van-image-figure inline-layout\" data-bordeaux-image-check=\"\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\" style=\"max-width:5252px;\">\n<p class=\"vanilla-image-block\" style=\"padding-top:56.25%;\"><picture><source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-320-80.jpg.webp 320w, https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-1200-80.jpg.webp 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\"\/><img decoding=\"async\" alt=\"Three older men sit on a bench facing the camera. All three have stick-shaped mobility aids. The backdrop includes flowering bushes and a red-trimmed building.\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-320-80.jpg 320w, https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-480-80.jpg 480w, https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-650-80.jpg 650w, https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-970-80.jpg 970w, https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-1024-80.jpg 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k-1200-80.jpg 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\" loading=\"lazy\" src=\"https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k.jpg\" data-pin-media=\"https:\/\/cdn.mos.cms.futurecdn.net\/tk9w8gqx58ko4kcd4REF5k.jpg\"\/><\/picture><\/p>\n<\/div>\n<\/div><figcaption itemprop=\"caption description\" class=\" inline-layout\"><span class=\"caption-text\">Three men sit on a bench in Antioquia, Colombia. <\/span><span class=\"credit\" itemprop=\"copyrightHolder\">(Image credit: Eric Nathan\u00a0\/ Alamy\u00a0Stock Photo)<\/span><\/figcaption><\/figure>\n<p>A genetically isolated community in northwest Colombia, called the Antioque\u00f1os or Paisas, carries a rare genetic variant that puts people at increased risk of early-onset Alzheimer&#8217;s disease (AD).<\/p>\n<p>The province of Antioquia was founded by a small population of <a data-analytics-id=\"inline-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12601469\/\" target=\"_blank\" data-url=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12601469\/\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>Spanish men and Indigenous women<\/u><\/a>, and a 2006 study in the journal <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.pnas.org\/doi\/full\/10.1073\/pnas.0508716103\" target=\"_blank\" data-url=\"https:\/\/www.pnas.org\/doi\/full\/10.1073\/pnas.0508716103\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>PNAS<\/u><\/a> found that their descendants continued to pair up with Spanish men, but not with Indigenous women or men. Over time, this likely created a genetically isolated population, the study found. Many Antioque\u00f1os carry a <a data-analytics-id=\"inline-link\" href=\"https:\/\/nihrecord.nih.gov\/2022\/08\/19\/colbos-study-reveals-mysteries-alzheimer-s-disease\" target=\"_blank\" data-url=\"https:\/\/nihrecord.nih.gov\/2022\/08\/19\/colbos-study-reveals-mysteries-alzheimer-s-disease\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>rare genetic mutation<\/u><\/a> that leads to cognitive impairment by age 45 and AD by age 50 \u2014 people typically develop the disease after age 65. But by studying this group, researchers hope to develop <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.livescience.com\/antibodies.html\" data-before-rewrite-localise=\"https:\/\/www.livescience.com\/antibodies.html\"><u>antibodies<\/u><\/a> that could protect people against AD in the future.<\/p>\n<h2 id=\"7-ashkenazi-jews-3\">7. Ashkenazi Jews<\/h2>\n<figure class=\"van-image-figure inline-layout\" data-bordeaux-image-check=\"\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\" style=\"max-width:3186px;\">\n<p class=\"vanilla-image-block\" style=\"padding-top:56.25%;\"><picture><source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-320-80.jpg.webp 320w, https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-1200-80.jpg.webp 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\"\/><img decoding=\"async\" alt=\"A doctor takes blood from a woman's arm\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-320-80.jpg 320w, https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-480-80.jpg 480w, https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-650-80.jpg 650w, https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-970-80.jpg 970w, https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-1024-80.jpg 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5-1200-80.jpg 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\" loading=\"lazy\" src=\"https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5.jpg\" data-pin-media=\"https:\/\/cdn.mos.cms.futurecdn.net\/bpgchMPmuC3F6qHC7o9vy5.jpg\"\/><\/picture><\/p>\n<\/div>\n<\/div><figcaption itemprop=\"caption description\" class=\" inline-layout\"><span class=\"caption-text\">A doctor draws blood from a woman during a screening program for the Ashkenazi Jewish community <\/span><span class=\"credit\" itemprop=\"copyrightHolder\">(Image credit: Rick Friedman \/\u00a0Getty Images)<\/span><\/figcaption><\/figure>\n<p>This Jewish diaspora group migrated from the Middle East and into Central and Eastern Europe in several waves, including one following the Crusades. A 2006 study in the <a data-analytics-id=\"inline-link\" href=\"https:\/\/doi.org\/10.1086\/500307\" target=\"_blank\" data-url=\"https:\/\/doi.org\/10.1086\/500307\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>American Journal of Human Genetics<\/u><\/a> showed that around half of the 8 million Ashkenazi Jews living today can trace their maternal lineage to just four original groups. Later a 2022 study in the journal <a data-analytics-id=\"inline-link\" href=\"https:\/\/doi.org\/10.1016\/j.cell.2022.11.002\" target=\"_blank\" data-url=\"https:\/\/doi.org\/10.1016\/j.cell.2022.11.002\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>Cell<\/u><\/a> revealed that this founder event happened at least seven centuries ago.<\/p>\n<p>One potential issue with founder events is that inherited disorders can become more common in the population, because a small gene pool may &#8220;trap&#8221; gene variants. <a data-analytics-id=\"inline-link\" href=\"https:\/\/rarediseases.org\/rare-diseases\/tay-sachs-disease\/#disease-overview-main\" target=\"_blank\" data-url=\"https:\/\/rarediseases.org\/rare-diseases\/tay-sachs-disease\/#disease-overview-main\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>Tay-Sachs disease<\/u><\/a>, a brain and spinal cord disorder that affects children, is rare in the general worldwide population but is more common in Ashkenazi Jews, with about 1 in 3,500 children in the population affected at birth. The condition also crops up in the Amish \u2014 another genetically isolated group.<\/p>\n<h2 id=\"8-finns-3\">8. Finns<\/h2>\n<figure class=\"van-image-figure inline-layout\" data-bordeaux-image-check=\"\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\" style=\"max-width:5467px;\">\n<p class=\"vanilla-image-block\" style=\"padding-top:56.25%;\"><picture><source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-320-80.jpg.webp 320w, https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-1200-80.jpg.webp 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\"\/><img decoding=\"async\" alt=\"Several people stand in a line; they wear white caps with a black band and colorful outfits.\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-320-80.jpg 320w, https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-480-80.jpg 480w, https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-650-80.jpg 650w, https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-970-80.jpg 970w, https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-1024-80.jpg 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c-1200-80.jpg 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\" loading=\"lazy\" src=\"https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c.jpg\" data-pin-media=\"https:\/\/cdn.mos.cms.futurecdn.net\/x3ajJa8qztjVuDSWmitX3c.jpg\"\/><\/picture><\/p>\n<\/div>\n<\/div><figcaption itemprop=\"caption description\" class=\" inline-layout\"><span class=\"caption-text\">A group of young Finnish people celebrating Walpurgis day <\/span><span class=\"credit\" itemprop=\"copyrightHolder\">(Image credit: Jarmo Piironen\u00a0\/ Alamy\u00a0Stock Photo)<\/span><\/figcaption><\/figure>\n<p>Over the course of its history, Finland has had at least <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.pfizer.com\/news\/articles\/how-finland%E2%80%99s-unique-genetic-heritage-being-used-study-links-between-genes-and\" target=\"_blank\" data-url=\"https:\/\/www.pfizer.com\/news\/articles\/how-finland%E2%80%99s-unique-genetic-heritage-being-used-study-links-between-genes-and\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>two major population bottlenecks<\/u><\/a>, in which the population dwindled in number but then resurged. These bottlenecks, plus the relatively sparsely populated and geographically isolated nature of the country, led to an increase in the frequency of certain gene variants.<\/p>\n<p>The Finns created a database, called <a data-analytics-id=\"inline-link\" href=\"https:\/\/journals.biologists.com\/dmm\/article\/15\/10\/dmm049490\/278566\/The-Finnish-genetic-heritage-in-2022-from\" target=\"_blank\" data-url=\"https:\/\/journals.biologists.com\/dmm\/article\/15\/10\/dmm049490\/278566\/The-Finnish-genetic-heritage-in-2022-from\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>Finnish Disease Heritage<\/u><\/a>, that catalogues dozens of recessive genetic disorders commonly seen in ethnic Finns that can severely affect their health, including types of epilepsy and muscular dystrophy. On the other hand, the Finns&#8217; unique genetics make other conditions \u2014 such as cystic fibrosis and <a data-analytics-id=\"inline-link\" href=\"https:\/\/medlineplus.gov\/genetics\/condition\/phenylketonuria\/\" target=\"_blank\" data-url=\"https:\/\/medlineplus.gov\/genetics\/condition\/phenylketonuria\/\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>phenylketonuria<\/u><\/a> \u2014 rare in people of ethnic Finnish heritage.<\/p>\n<h2 id=\"9-tristan-da-cunha-3\">9. Tristan da Cunha<\/h2>\n<figure class=\"van-image-figure inline-layout\" data-bordeaux-image-check=\"\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\" style=\"max-width:2007px;\">\n<p class=\"vanilla-image-block\" style=\"padding-top:66.67%;\"><picture><source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-320-80.jpg.webp 320w, https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-1200-80.jpg.webp 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\"\/><img decoding=\"async\" alt=\"A sign on Tristan da Cunha that reads: Welcome to the remotest island. There is an illustration of the island on the sign.\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-320-80.jpg 320w, https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-480-80.jpg 480w, https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-650-80.jpg 650w, https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-970-80.jpg 970w, https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-1024-80.jpg 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd-1200-80.jpg 1200w\" sizes=\"(min-width: 1000px) 970px, calc(100vw - 40px)\" loading=\"lazy\" src=\"https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd.jpg\" data-pin-media=\"https:\/\/cdn.mos.cms.futurecdn.net\/VJsZo2A3eVCvgHWVP4pqBd.jpg\"\/><\/picture><\/p>\n<\/div>\n<\/div><figcaption itemprop=\"caption description\" class=\" inline-layout\"><span class=\"caption-text\">A sign on the island of Tristan da Cunha welcomes visitors <\/span><span class=\"credit\" itemprop=\"copyrightHolder\">(Image credit: David Forman\/Getty Images)<\/span><\/figcaption><\/figure>\n<p>Tristan da Cunha, in the south Atlantic Ocean, is part of the most remote inhabited archipelago in the world. Today, it is a part of the British Overseas Territories and is home to only about 250 permanent residents. But when it was first settled in 1816, <a data-analytics-id=\"inline-link\" href=\"https:\/\/go.redirectingat.com\/?id=92X1590019&amp;xcust=livescience_us_7452954252768104826&amp;xs=1&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2F5201022&amp;sref=https%3A%2F%2Fwww.livescience.com%2Fhealth%2F9-of-the-most-genetically-isolated-human-populations-in-the-world\" target=\"_blank\" data-url=\"https:\/\/www.nature.com\/articles\/5201022\" referrerpolicy=\"no-referrer-when-downgrade\" rel=\"sponsored noopener\" data-hl-processed=\"skimlinks\" data-placeholder-url=\"https:\/\/go.redirectingat.com\/?id=92X1590019&amp;xcust=hawk-custom-tracking&amp;xs=1&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2F5201022&amp;sref=https%3A%2F%2Fwww.livescience.com%2Fhealth%2F9-of-the-most-genetically-isolated-human-populations-in-the-world\" data-google-interstitial=\"false\" data-merchant-name=\"SkimLinks - nature.com\" data-merchant-id=\"undefined\" data-merchant-url=\"undefined\" data-merchant-network=\"undefined\"><u>the population<\/u><\/a> was somewhere between 15 and 28 people, making Tristan a textbook example of a founder effect.<\/p>\n<p>A <a data-analytics-id=\"inline-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/13978332\/\" target=\"_blank\" data-url=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/13978332\/\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>study published in the 1960s<\/u><\/a> found that the Tristan population had a higher-than-expected number of people affected by retinitis pigmentosa, an inherited eye disease that causes vision loss, and a <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.cambridge.org\/core\/journals\/twin-research-and-human-genetics\/article\/variation-at-dennd1b-and-asthma-on-the-island-of-tristan-da-cunha\/3B5F6BEB2DA763AA1120A02AC6E727F1\" target=\"_blank\" data-url=\"https:\/\/www.cambridge.org\/core\/journals\/twin-research-and-human-genetics\/article\/variation-at-dennd1b-and-asthma-on-the-island-of-tristan-da-cunha\/3B5F6BEB2DA763AA1120A02AC6E727F1\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>2019 study<\/u><\/a> revealed abnormally high frequencies of asthma within the population.<\/p>\n<\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.livescience.com\/health\/9-of-the-most-genetically-isolated-human-populations-in-the-world\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Over the past 50,000 years, humans have populated nearly every corner of the globe \u2014 and due to geographic barriers, some of these populations then remained isolated for thousands or &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=138370\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-138370","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/138370","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=138370"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/138370\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=138370"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=138370"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=138370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}