{"id":138591,"date":"2024-12-19T00:47:16","date_gmt":"2024-12-18T17:47:16","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=138591"},"modified":"2024-12-19T00:47:16","modified_gmt":"2024-12-18T17:47:16","slug":"circadian-clock-influences-inflammation-and-disease","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=138591","title":{"rendered":"Circadian Clock Influences Inflammation and Disease"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>New research reveals how the body\u2019s circadian clock regulates macrophage activity, influencing immune system inflammation throughout the day. Activation of the NLRP3 inflammasome, a key component in the immune response, peaks during the morning when macrophages are most efficient. This daily rhythm is driven by mitochondrial activity, explaining why inflammatory conditions like arthritis often worsen in the morning.<\/p>\n<p>The findings open doors to time-targeted therapies, potentially improving treatments for diseases driven by overactive inflammasomes. Understanding the immune system\u2019s internal clock could lead to precise interventions for inflammatory disorders.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li><strong>Daily Immune Rhythms:<\/strong> The body\u2019s clock regulates macrophage inflammasome activation, peaking in the morning.<\/li>\n<li><strong>Mitochondrial Role:<\/strong> Mitochondria drive the time-dependent changes in immune response.<\/li>\n<li><strong>Therapeutic Potential:<\/strong> Timing treatments to immune activity cycles could improve inflammatory disease management.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>RCSI<\/p>\n<p><strong>New research from RCSI University of Medicine and Health Sciences has explained how the body\u2019s internal clock influences the inflammatory process of the immune system. <\/strong><\/p>\n<p>The findings describe how immune cells, called macrophages, work differently at various times of the day and could pave the way for time-targeted treatments for inflammatory diseases such as arthritis.<\/p>\n<p>The researchers explored the link between the immune system and the body\u2019s circadian rhythms often referred to as the body clock. Macrophages, immune cells that detect and respond to harmful substances, are able to trigger inflammation as a defense mechanism by assembling large complexes known as inflammasomes.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-107163\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience.jpg\" alt=\"This shows a clock and viruses.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/12\/circadian-clock-inflammation-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">The research also highlights a key role for mitochondria, the cell\u2019s energy producers, in driving these daily changes in immune activity. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>Inflammasomes could be compared to \u2018smoke detectors\u2019 that will then alert the immune system of danger.<\/p>\n<p>Activation of an inflammasome called NLRP3 was not found to be constant throughout the day but was regulated by the body\u2019s 24-hour circadian clock. This daily rhythm determines when macrophages are most efficient at detecting threats and when their energy levels peak to mount a response.<\/p>\n<p>The research also highlights a key role for mitochondria, the cell\u2019s energy producers, in driving these daily changes in immune activity.<\/p>\n<p>\u201cWhen macrophages \u2018think\u2019 it\u2019s morning, their inflammasome activation is quicker and more robust,\u201d explained Professor Annie Curtis, Principal investigator for the study at RCSI School of Pharmacy and Biomolecular Sciences.<\/p>\n<p>\u201cThis means the immune response is heightened during the early part of the day, a time when we are awake and more likely to encounter environmental challenges, such as injuries or infections.\u201d<\/p>\n<p>The study has significant implications for understanding and treating inflammatory diseases, such as arthritis, where overactive inflammasomes play a key role. Symptoms of such diseases often worsen in the morning, something this research may help explain.<\/p>\n<p>\u201cWith these findings, there\u2019s potential to refine treatments for inflammatory conditions,\u201d said Dr James O\u2019Siorain, lead author of the study.<\/p>\n<p>\u201cFor instance, new therapies targeting inflammasomes could be more effective if administered at specific times of the day when macrophage activity peaks.\u201d<\/p>\n<p><strong>Funding:<\/strong> The research was supported by funding from Taighde \u00c9ireann \u2013 Research Ireland.\u00a0<\/p>\n<h2 class=\"wp-block-heading\">About this circadian rhythm and inflammation research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#e38f82969182828d878691908c8da39180908acd8a86\" target=\"_blank\" rel=\"noreferrer noopener\">Laura Anderson<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/rcsi.ie\" target=\"_blank\" rel=\"noreferrer noopener\">RCSI<\/a><br \/><strong>Contact: <\/strong>Laura Anderson \u2013 RCSI<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/doi.org\/10.1096\/fj.202400508RR\" target=\"_blank\" rel=\"noreferrer noopener\">Time of day control of mitochondria regulates NLRP3 inflammasome activation in macrophages<\/a>\u201d by Annie Curtis et al. <em><em>FASEB Journal<\/em><\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Time of day control of mitochondria regulates NLRP3 inflammasome activation in macrophages<\/strong><\/p>\n<p>Macrophages are innate immune cells that orchestrate the process of inflammation, which varies across time of day. This ensures appropriate biological timing of the immune response with the external environment.<\/p>\n<p>The NLRP3 inflammasome mediates IL-1-family cytokine release via pyroptosis. Mitochondria play a multifaceted role regulating NLRP3 inflammasome activity.<\/p>\n<p>Mitochondria exhibit distinct metabolic changes across time of day, which are influenced by clock genes. However, whether the macrophage clock regulates the NLRP3 inflammasome via mitochondrial control remains unclear.<\/p>\n<p>We find heightened mitochondrial membrane potential (\u0394\u03c8m) and enhanced NLRP3 inflammasome activation from peritoneal exudate cells (PECs) isolated at circadian time (CT) 12 compared to CT 0.<\/p>\n<p>In\u00a0vitro time-of-day synchronization of bone-marrow derived macrophages (BMDMs) induced time-dependent differences in NLRP3 inflammasome activation.<\/p>\n<p>Myeloid-specific\u00a0<em>Bmal1<\/em>-deletion enhanced NLRP3 inflammasome activity in PECs at CT0 and in unsynchronized BMDMs compared to controls.<\/p>\n<p>Pharmacologically disrupting \u0394\u03c8m in synchronized cells reduced NLRP3 inflammasome activation to comparable levels, and the same occurred with\u00a0<em>Bmal1<\/em>-deletion.<\/p>\n<p>These results further demonstrate circadian clock timing of the NLRP3 inflammasome, which is dependent on mitochondrial function and driven through the circadian gene\u00a0<em>Bmal1<\/em>.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/circadian-clock-inflammation-28271\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: New research reveals how the body\u2019s circadian clock regulates macrophage activity, influencing immune system inflammation throughout the day. 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