{"id":138728,"date":"2024-12-19T09:36:09","date_gmt":"2024-12-19T02:36:09","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=138728"},"modified":"2024-12-19T09:36:09","modified_gmt":"2024-12-19T02:36:09","slug":"why-some-people-can-get-away-with-only-a-little-sleep-every-night","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=138728","title":{"rendered":"Why some people can get away with only a little sleep every night"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>But in recent years, scientists have discovered a rare breed who consistently get little shut-eye and are no worse for wear.<\/p>\n<p><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/short-sleeper-syndrome-sss\">Natural short sleepers<\/a>, as they are called, are genetically wired to need only four to six hours of sleep a night. These outliers suggest that quality, not quantity, is what matters. If scientists could figure out what these people do differently it might, they hope, provide insight into sleep\u2019s very nature.<\/p>\n<p><a href=\"https:\/\/www.pbs.org\/newshour\/show\/study-finds-night-owls-have-superior-cognitive-function-compared-to-early-risers\"><strong>WATCH:<\/strong> Study finds night owls have \u2018superior cognitive function\u2019 compared to early risers<\/a><\/p>\n<p>\u201cThe bottom line is, we don\u2019t understand what sleep is, let alone what it\u2019s for. That\u2019s pretty incredible, given that the average person sleeps a third of their lives,\u201d says <a href=\"https:\/\/profiles.ucsf.edu\/louis.ptacek\">Louis Pt\u00e1\u010dek<\/a>, a neurologist at the University of California San Francisco.<\/p>\n<p>Scientists once thought <a href=\"https:\/\/knowablemagazine.org\/content\/article\/health-disease\/2021\/why-sleep-matters-personal-and-public-health\">sleep<\/a> was little more than a period of rest, like powering down a computer in preparation for the next day\u2019s work. Thomas Edison called sleep a waste of time \u2014 \u201c<a href=\"https:\/\/ieeexplore.ieee.org\/document\/6891047\">a heritage from our cave days<\/a>\u201d \u2014 and claimed to never sleep more than four hours a night. His invention of the incandescent lightbulb encouraged shorter sleep times in others. Today, a historically high number of US adults are sleeping less than five hours a night.<\/p>\n<p>But modern sleep research has shown that sleep is an active, complicated process we don\u2019t necessarily want to cut short. During sleep, scientists suspect that our bodies and brains are <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2948963\/\">replenishing energy stores<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24136970\/\">flushing waste and toxins<\/a>, pruning synapses and <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0896627323002015\">consolidating memories<\/a>. As a result, chronic sleep deprivation can have <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22654183\/\">serious health consequences<\/a>.<\/p>\n<p>Most of what we know about sleep and sleep deprivation stems from a model proposed in the 1970s by a Hungarian-Swiss researcher named Alexander Borb\u00e9ly. His <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9540767\/#:~:text=FIRST%20VERSIONS%20OF%20THE%20MODEL,be%20related%20(Figure%201).\">two-process model<\/a> of sleep describes how separate systems \u2014 circadian rhythm and sleep homeostasis \u2014 interact to govern when and how long we sleep. The <a href=\"https:\/\/knowablemagazine.org\/content\/article\/living-world\/2019\/circadian-rhythm-drugs\">circadian clock<\/a> dictates the 24-hour cycle of sleep and wakefulness, guided by external cues like light and darkness. Sleep homeostasis, on the other hand, is driven by internal pressure that builds while you\u2019re awake and decreases while you\u2019re asleep, ebbing and flowing like hunger.<\/p>\n<p>There\u2019s variation in these patterns. \u201cWe\u2019ve always known that there are morning larks and night owls, but most people fall in between. We\u2019ve always known there are short sleepers and long sleepers, but most people fall in between,\u201d says Pt\u00e1\u010dek<em>. <\/em>\u201cThey\u2019ve been out there, but the reason that they haven\u2019t been recognized is that these people generally don\u2019t go to doctors.\u201d<\/p>\n<p>That changed when Pt\u00e1\u010dek and his colleague <a href=\"https:\/\/profiles.ucsf.edu\/ying-hui.fu\">Ying-Hui Fu<\/a>, a human geneticist and neuroscientist at UC San Francisco, were introduced to a woman who felt that her early sleep schedule <a href=\"https:\/\/magazine.ucsf.edu\/science-sleep\">was a curse<\/a>. The woman naturally woke up in the wee hours of the morning, when it was \u201ccold, dark, and lonely.\u201d Her granddaughters inherited her same sleep habits. The researchers pinpointed the <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11232563\/\">genetic mutation for this rare type of morning lark,<\/a> and after they published their findings, thousands of extreme early risers came out of the woodwork.<\/p>\n<p>But Fu recalls being intrigued by one family that didn\u2019t fit the pattern. These family members woke up early but didn\u2019t go to bed early, and felt refreshed after only about six hours of sleep. They were the first people identified with familial natural short sleep, a condition that runs in families like other genetic traits. Fu and Pt\u00e1\u010dek traced their abbreviated slumber to a <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.1174443\">mutation in a gene called <em>DEC2<\/em><\/a>.<\/p>\n<p>The researchers went on to genetically engineer the <em>DEC2<\/em> mutation into mice, showing that the animals need less sleep than their littermates. And they found that <a href=\"https:\/\/www.pnas.org\/doi\/abs\/10.1073\/pnas.1801693115\">one of the gene\u2019s jobs is to help control levels of a brain hormone called orexin<\/a>, which promotes wakefulness. Interestingly, orexin deficiency is a leading cause of narcolepsy, a sleep disorder marked by episodes of excessive daytime sleepiness. In people with short sleep, however, orexin production appears to be increased.<\/p>\n<p>Over time, the team has identified seven genes associated with natural short sleep. In one family with three generations of short sleepers, the researchers found a <a href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(19)30652-X\">mutation in a gene called <em>ADRB1<\/em><\/a>, which is highly active in a region of the brain stem, the dorsal pons, that\u2019s involved in regulating sleep. When the scientists used a technique to stimulate that brain region in mice, rousing them from their sleep, mice with the <em>ADRB1<\/em> mutation woke more easily and stayed awake longer.<\/p>\n<p>In a father-son pair of short sleepers, the researchers identified a <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7587149\/\">mutation in another gene, <em>NPSR1<\/em><\/a>, which is involved in regulating the sleep\/wake cycle<em>.<\/em> When they created mice with the same mutation, they found that the animals spent less time sleeping and, in behavioral tests, lacked the memory problems that typically follow a short night\u2019s sleep.<\/p>\n<p>The team also found two distinct mutations in a <a href=\"https:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(20)31441-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS096098222031441X%3Fshowall%3Dtrue\">gene called <em>GRM1<\/em><\/a>, in two unrelated families with shortened sleep cycles. Again, mice engineered with those mutations slept less, with no obvious health consequences.<\/p>\n<p>Like mice, people who are naturally short sleepers seem to be immune to the ill effects of sleep deprivation. If anything, <a href=\"https:\/\/www.annualreviews.org\/content\/journals\/10.1146\/annurev-genom-121222-120306\">they do extraordinarily well<\/a>. Research suggests that such people are ambitious, energetic and optimistic, with remarkable resilience against stress and higher thresholds for pain. They might even live longer.<\/p>\n<p>Based on the findings in short sleepers, some researchers think it may be time to update the old two-process model of sleep, which is how Pt\u00e1\u010dek developed the idea of a third influence. The updated model might unfold like this: In the morning, the circadian clock indicates it is time to start your day, and sleep homeostasis signals you\u2019ve gotten enough sleep to get out of bed. Then a third factor \u2014 behavioral drive \u2014 compels you to go out and do your job, or find a mate, or gather sustenance. At night, the process goes in reverse, to calm the body down for sleep.<\/p>\n<p>Perhaps short sleepers are so driven that they are able to overcome the innate processes that keep others in bed<strong>.<\/strong> But it may also be that, somehow, the brains of short sleepers are built to sleep so efficiently that they are able to do more with less.<\/p>\n<h2>Efficient slumber<\/h2>\n<p>\u201cIt\u2019s not like there\u2019s something magical about your seven to eight hours,\u201d says <a href=\"https:\/\/www.feinberg.northwestern.edu\/sites\/sleep\/members\/profile.html?xid=13785\">Phyllis Zee<\/a>, director of the Center for Circadian and Sleep Medicine at Northwestern University, near Chicago. Zee can imagine countless ways that short sleepers\u2019 brains could be more efficient. Do they have more slow-wave sleep, the most restorative sleep stage? Do they generate higher amounts of cerebrospinal fluid, the liquid that bathes the brain and spinal cord, enabling them to get rid of more waste products? Is their metabolic rate different, helping them cycle in and out of sleep more quickly?<\/p>\n<p>\u201cIt\u2019s all about efficiency, sleep efficiency \u2014 that\u2019s how I feel,\u201d says Fu. \u201cWhatever their body needs to do with sleep, they can get it done in a short time.\u201d<\/p>\n<p><a href=\"https:\/\/www.pbs.org\/newshour\/science\/why-you-slept-lousy-on-vacation\"><strong>READ MORE:<\/strong> Why you sleep lousy on vacation<\/a><\/p>\n<p>Recent studies from Fu and Pt\u00e1\u010dek suggest that naturally short sleepers may be more efficient at removing toxic brain aggregates that contribute to neurodegenerative disorders like Alzheimer\u2019s disease. The researchers bred mice that had <a href=\"https:\/\/www.cell.com\/iscience\/fulltext\/S2589-0042(22)00234-6\">short<\/a> <a href=\"https:\/\/www.pnas.org\/doi\/full\/10.1073\/pnas.2221686120\">sleep<\/a> genes with mice that carried genes predisposing them to Alzheimer\u2019s. The Alzheimer\u2019s mice developed a buildup of abnormal proteins \u2014 amyloid plaques and tau tangles \u2014 that, in humans, are hallmarks of dementia. But the brains of the hybrid mice developed fewer of these tangles and plaques, as if the sleep mutations were protecting the animals.<\/p>\n<p>Fu believes that if she conducted similar studies in models of heart disease, diabetes or other illnesses associated with sleep deprivation, she would get similar results.<\/p>\n<h2>Deeper secrets of sleep<\/h2>\n<p>It isn\u2019t yet clear how the short sleeper genes identified thus far shield people from the ill effects of poor sleep, or how the mutations in these genes make sleep more efficient. To get at the answer, Fu and Pt\u00e1\u010dek started bringing short sleepers to their joint laboratory to measure their brain waves while they slept. Their sleep study was derailed by the pandemic, but they are eager to get it back on track.<\/p>\n<p>The researchers are also interested in understanding other sleep outliers. Sleep duration, like most behaviors, follows a bell curve. Short sleepers sit on one end of the curve, long sleepers on the other<em>. <\/em>Fu has found one genetic mutation associated with long sleep, but long sleepers are challenging to study because their schedules don\u2019t align with the norms and demands of society. Long sleepers are often forced to get up early to go to school or work, which can result in sleep deprivation and may contribute to depression and other illnesses.<\/p>\n<p><a href=\"https:\/\/www.pbs.org\/newshour\/show\/not-getting-enough-sleep-heres-how-researchers-say-it-affects-your-health\"><strong>WATCH:<\/strong> Not getting enough sleep? Here\u2019s how researchers say it affects your health<\/a><\/p>\n<p>But though sleep has a strong genetic component, it can also be shaped by the environment. Knowing that better sleep is possible, and understanding the basis, could point the way to interventions to optimize sleep, enabling more people to live longer, healthier lives.<\/p>\n<p>Zee\u2019s lab, for example, has tinkered with using <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5340797\/\">acoustic stimulation<\/a> to boost the slow waves of deep sleep that enhance memory processing and may be one of the secrets to short sleepers\u2019 success. In a study, they played pink noise \u2014 a softer, more natural sound than white noise, more akin to rain or the ocean \u2014 while study participants slept. The next day those participants remembered more in a test of learning and recalling word pairs. \u201cWe can enhance memory, but we\u2019re not making them sleep longer or necessarily shorter,\u201d says Zee. \u201cI think there\u2019s a lot more to learn.\u201d<\/p>\n<p>For now, researchers recommend that people focus on getting the amount of sleep they need, recognizing it will be different for different people. Pt\u00e1\u010dek still bristles when he hears someone preach that everybody has to sleep eight hours a night. \u201cThat\u2019s like saying everybody in the population has to be 5 foot 10,\u201d he says. \u201cThat\u2019s not how genetics works.\u201d<\/p>\n<p><em>This\u00a0<a href=\"https:\/\/knowablemagazine.org\/content\/article\/mind\/2024\/genetics-of-people-who-need-little-sleep\">article<\/a>\u00a0originally appeared in\u00a0<a href=\"https:\/\/www.knowablemagazine.org\/\">Knowable Magazine<\/a>, an independent journalistic endeavor from Annual Reviews.<\/em><\/p>\n<p><h6>10.1146\/knowable-121124-1<\/h6>\n<\/p>\n<\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.pbs.org\/newshour\/health\/why-some-people-can-get-away-with-only-a-little-sleep-every-night\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>But in recent years, scientists have discovered a rare breed who consistently get little shut-eye and are no worse for wear. Natural short sleepers, as they are called, are genetically &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=138728\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8628],"tags":[],"class_list":["post-138728","post","type-post","status-publish","format-standard","hentry","category-science","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/138728","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=138728"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/138728\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=138728"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=138728"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=138728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}